Most reliable cars = Acura TSX & Acura TL

Most Reliable Upscale/Large Car

Most reliable (Best score first)

Lexus ES350
Lincoln Zephyr
Hyundai Azera
Acura TSX
Acura TL

Least reliable (Worst score first) Jaguar X-type
Chrysler 300 (V8)
Saab 9-3

Full article found on CNNMoney.com - Most Reliable Cars.